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KMID : 0191120160310071082
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Journal of Korean Medical Science
2016 Volume.31 No. 7 p.1082 ~ p.1088
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Early Changes in the Serotype Distribution of Invasive Pneumococcal Isolates from Children after the Introduction of Extended-valent Pneumococcal Conjugate Vaccines in Korea, 2011-2013
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Cho Eun-Young
Choi Eun-Hwa
Kang Jin-Han
Kim Kyung-Hyo
Kim Dong-Soo
Kim Yae-Jean
Ahn Young-Min
Eun Byung-Wook
Oh Sung-Hee
Cha Sung-Ho
Cho Hye-Kyung
Hong Young-Jin
Kim Kwang-Nam
Kim Nam-Hee
Kim Yun-Kyung
Kim Jong-Hyun
Lee Hyun-ju
Lee Taek-Jin
Kim Hwang-Min
Lee Kun-Song
Kim Chun-Soo
Park Su-Eun
Kim Young-Mi
Oh Chi-Eun
Ma Sang-Hyuk
Jo Dae-Sun
Choi Young-Youn
Lee Ji-Na
Bae Geun-Ryang
Park Ok
Park Young-Joon
Kim Eun-Seong
Lee Hoan-Jong
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Abstract
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This study was performed to measure early changes in the serotype distribution of pneumococci isolated from children with invasive disease during the 3-year period following the introduction of 10- and 13-valent pneumococcal conjugate vaccines (PCVs) in Korea. From January 2011 to December 2013 at 25 hospitals located throughout Korea, pneumococci were isolated among children who had invasive pneumococcal disease (IPD). Serotypes were determined using the Quellung reaction, and the change in serotype distribution was analyzed. Seventy-five cases of IPD were included. Eighty percent of patients were aged 3-59 months, and 32% had a comorbidity that increased the risk of pneumococcal infection. The most common serotypes were 19A (32.0%), 10A (8.0%), and 15C (6.7%). The PCV7 serotypes (4, 6B, 9V, 14, 18C, 19F, 23F, and 6A) accounted for 14.7% of the total isolates and the PCV13 minus PCV7 types (1, 3, 5, 7F and 19A) accounted for 32.0% of the total isolates. Serotype 19A was the only serotype in the PCV13 minus PCV7 group. The proportion of serotype 19A showed decreasing tendency from 37.5% in 2011 to 22.2% in 2013 (P = 0.309), while the proportion of non-PCV13 types showed increasing tendency from 45.8% in 2011 to 72.2% in 2013 (P = 0.108). Shortly after the introduction of extended-valent PCVs in Korea, serotype 19A continued to be the most common serotype causing IPD in children. Subsequently, the proportion of 19A decreased, and non-vaccine serotypes emerged as an important cause of IPD. The impact of extended-valent vaccines must be continuously monitored.
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KEYWORD
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Streptococcus pneumoniae, Serotype, Pneumococcal Vaccines
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